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256 results
2021
Andrian UH. NK cell memory: discovery of a mystery. Nature Immunology. 2021.
Andrian UH. NK cell memory: discovery of a mystery. Nature Immunology. 2021.
Ulrich von Andrian recounts how an unexpected experimental result called into question a well-established concept in immunology: the mechanism of immune memory. Follow-up experiments revealed that NK cells can mediate antigen-specific adaptive immune...
Kochappan R, Cao E, Han S, Hu L, Quach T, Senyschyn D, Ferreira VI, Lee G, Leong N, Sharma G, et al. Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice. Journal of Controlled Release. 2021;(332):636–651.
Kochappan R, Cao E, Han S, Hu L, Quach T, Senyschyn D, Ferreira VI, Lee G, Leong N, Sharma G, et al. Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice. Journal of Controlled Release. 2021;(332):636–651.
The mesenteric lymph nodes (MLN) are a key site for the generation of adaptive immune responses to gut-derived antigenic material and immune cells within the MLN contribute to the pathophysiology of a range of conditions including inflammatory and...
Stutte S, Ruf J, Kugler I, Ishikawa-Ankerhold H, Parzefall A, Marconi P, Maeda T, Kaisho T, Krug A, Popper B, et al. Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain Behavior and Immunity. 2021.
Stutte S, Ruf J, Kugler I, Ishikawa-Ankerhold H, Parzefall A, Marconi P, Maeda T, Kaisho T, Krug A, Popper B, et al. Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain Behavior and Immunity. 2021.
Loss of appetite (anorexia) is a typical behavioral response to infectious diseases that often reduces body weight. Also, anorexia can be observed in cancer and trauma patients, causing poor quality of life and reduced prospects of positive therapeutic...
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, et al. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity. 2021.
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, et al. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity. 2021.
Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in aged mice, neutrophils adhered to vascular endothelium in inflamed tissues...
Vollmann E, Rattay K, Barreiro O, Thiriot A, Fuhlbrigge R, Vrbanac V, Kim K-W, Jung S, Tager A, Andrian UH. Specialized transendothelial dendritic cells mediate thymic T cell selection against blood-borne macromolecules. Nature Communications. 2021.
Vollmann E, Rattay K, Barreiro O, Thiriot A, Fuhlbrigge R, Vrbanac V, Kim K-W, Jung S, Tager A, Andrian UH. Specialized transendothelial dendritic cells mediate thymic T cell selection against blood-borne macromolecules. Nature Communications. 2021.
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T cells undergo rigorous selection in the thymus to ensure self-tolerance and prevent autoimmunity, with this process requiring innocuous self-antigens (Ags) to be presented to thymocytes. Self-Ags are either expressed by thymic stroma cells or...
Mysore V, Cullere X, Mears J, Rosetti F, Okubo K, Liew P, Zhang F, Madera-Salcedo I, Rosenbauer F, Stone R, et al. FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity. Nature Communications. 2021.
Mysore V, Cullere X, Mears J, Rosetti F, Okubo K, Liew P, Zhang F, Madera-Salcedo I, Rosenbauer F, Stone R, et al. FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity. Nature Communications. 2021.
Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate immunity and tolerance. Neutrophil-derived cells with properties of DCs (nAPC) are observed in human diseases and after culture of neutrophils with cytokines...
Marchetti, Francisco, Soldati, Jahromi, Barcos, Gruber, Pareja, Thiriot, Andrian, Deutsch, et al. ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro. European Journal of Immunology. 2021.
Marchetti, Francisco, Soldati, Jahromi, Barcos, Gruber, Pareja, Thiriot, Andrian, Deutsch, et al. ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro. European Journal of Immunology. 2021.
The migration of CD4+ effector/memory T cells across the blood-brain barrier (BBB) is a critical step in MS or its animal model, EAE. T-cell diapedesis across the BBB can occur paracellular, via the complex BBB tight junctions or transcellular via a pore...
2020
Zeng, Eljalby, Aryal, Lehoux, Stavenhagen, Kudelka, Wang Y, Wang J, Ju, Andrian UH, et al. Cosmc controls B cell homing. Nature Communications. 2020;11(3990).
Zeng, Eljalby, Aryal, Lehoux, Stavenhagen, Kudelka, Wang Y, Wang J, Ju, Andrian UH, et al. Cosmc controls B cell homing. Nature Communications. 2020;11(3990).
The molecular mechanisms regulating lymphocyte homing into lymph nodes are only partly understood. Here, we report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of protein O-glycosylation, induces developmental...
Perro M, Iannacone M, Andrian U, Peixoto A. Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection. Virulence. 2020:1640–1655.
Perro M, Iannacone M, Andrian U, Peixoto A. Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection. Virulence. 2020:1640–1655.
Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T...
Helble J, Gonzalez R, Andrian U, Starnbach M. Gamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract. American Society for Microbiology. 2020.
Helble J, Gonzalez R, Andrian U, Starnbach M. Gamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract. American Society for Microbiology. 2020.
While there is no effective vaccine against Chlamydia trachomatis infection, previous work has demonstrated the importance of C. trachomatis-specific CD4+ T cells (NR1 T cells) in pathogen clearance. Specifically, NR1 T cells have been shown to be...
2019
Rapp, Wintergerst, Kunz, Vetter, Knott, Lisowski, Haubner, Moder, Thaler, Eiber, et al. CCL22 Controls Immunity by Promoting Regulatory T Cell Communication With Dendritic Cells in Lymph Nodes. Journal of Experimental Medicine. 2019;216(5).
Rapp, Wintergerst, Kunz, Vetter, Knott, Lisowski, Haubner, Moder, Thaler, Eiber, et al. CCL22 Controls Immunity by Promoting Regulatory T Cell Communication With Dendritic Cells in Lymph Nodes. Journal of Experimental Medicine. 2019;216(5).
- description Publisher's Version
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Chemokines have crucial roles in organ development and orchestration of leukocyte migration. The chemokine CCL22 is expressed constitutively at high levels in the lymph node, but the functional significance of this expression is so far unknown. Studying a...
Ferber, Gonzalez, Cryer, Andrian, Artzi. Immunology-Guided Biomaterial’s Design as Mucosal Cancer Vaccine. Advanced Materials. 2019.
Ferber, Gonzalez, Cryer, Andrian, Artzi. Immunology-Guided Biomaterial’s Design as Mucosal Cancer Vaccine. Advanced Materials. 2019.
Cancer of mucosal tissues is a major cause of worldwide mortality for which only palliative treatments are available for patients with late-stage disease. Engineered cancer vaccines offer a promising approach for inducing antitumor immunity. The route of...