Quo vadis, neutrophil?


Gonzalez RJ, von Andrian UH. Quo vadis, neutrophil?. Cell. 2022;185 (5) :759-761.
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Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues.

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