Quo vadis, neutrophil?
Publication information:
Gonzalez RJ, Andrian UH. Quo vadis, neutrophil? Cell. 2022;185(5):759–761.
Abstract
Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues.