Search

Targeted Delivery of Immunomodulators to Lymph Nodes

Journal Article

Active-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node addressin molecules expressed by high endothelial venules of lymph nodes. By...

Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice

Journal Article

The mesenteric lymph nodes (MLN) are a key site for the generation of adaptive immune responses to gut-derived antigenic material and immune cells within the MLN contribute to the pathophysiology of a range of conditions including inflammatory and...

Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors

Journal Article

Natural killer (NK) cells are critical players against tumors. The outcome of anti-tumor vaccination protocols depends on the efficiency of NK-cell activation, and efforts are constantly made to manipulate them for immunotherapeutic approaches. Thus, a...

Bisphosphonates target B cells to enhance humoral immune responses

Journal Article

Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses...

The role of engineered materials in mucosal vaccination strategies

Journal Article

Mucosal pathogens, as exemplified by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human immunodeficiency virus (HIV) and Mycobacterium tuberculosis, lead to substantial morbidity and mortality worldwide and pose serious threats to global...

Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice

Journal Article

Peripheral lymph nodes (PLN) are critical for immunologic memory formation in response to antigens that penetrate the skin. Blood-borne lymphocytes first encounter such antigens after they home to PLN through a multi-step adhesion process that is normally...

Immunology-Guided Biomaterial's Design as Mucosal Cancer Vaccine

Journal Article

Cancer of mucosal tissues is a major cause of worldwide mortality for which only palliative treatments are available for patients with late-stage disease. Engineered cancer vaccines offer a promising approach for inducing antitumor immunity. The route of...

Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow

Journal Article

Nonirradiated bone marrow (BM) venules and sinusoids in murine skull support hematopoietic progenitor cell (HPC) rolling through constitutively expressed endothelial (P- and E-) selectins and VCAM-1. Using intravital microscopy, we tested whether host...

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Journal Article

Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading to potential adverse events and...

Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia

Journal Article

BACKGROUND: The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes ("enhanceosomes") that upregulate expression of select genes within the inflammatory...

Guiying Cheng

Person

Guiying received her MD from Xi’an Medical University (currently Xi’an Jiaotong University Medical School). She has a dozen of years of clinic surgery experience and currently is specialized in multiple mouse model surgeries, intravital microscopy...

Former Lab Members

Page

Pavel Hanc 2016 - 2026 Postdoctoral Research Fellow Gulbenkian Institute for Molecular Medicine, Group Leader Harold Roderick Neely 2016 - 2025 Postdoctoral Research Fellow Wenzhou-Kean University Yiyang Yao 2024 - 2025 Immunology Master's Student Marie...