Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells
Publication information:
Mora R, Andrian U. Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells. Immunity. 2004;21(4):458–60. doi:10.1016/j.immuni.2004.10.002
Abstract
T cell priming by dendritic cells (DC) from gut-associated lymphoid tissues gives rise to effector cells with pronounced gut tropism. The mechanism for DC-dependent imprinting of gut specificity has remained unknown. New findings point to retinoic acid, which is uniquely produced by intestinal DC, but not by DC from other lymphoid organs.