# von Andrian Laboratory ![Ear vasculature](/sites/g/files/omnuum3666/files/styles/hwp_21_9__1920x825/public/vonandrian/files/olga_ear_vasculature_1.jpg?itok=Z_8GmcBX) ## What We Do The von Andrian lab conducts basic research in immunology using a broad range of molecular cellular and whole animal approaches. We focus on the molecular mechanisms of immune cell migration and homing in lymphoid and non-lymphoid tissues using intravital microscopy techniques. --- ## Recent Publications Download 6 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1841486&content_filter%5B1%5D=1841616&content_filter%5B2%5D=1841601&content_filter%5B3%5D=1841596&content_filter%5B4%5D=1829196&content_filter%5B5%5D=1824731&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1841486&content_filter%5B1%5D=1841616&content_filter%5B2%5D=1841601&content_filter%5B3%5D=1841596&content_filter%5B4%5D=1829196&content_filter%5B5%5D=1824731&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1841486&content_filter%5B1%5D=1841616&content_filter%5B2%5D=1841601&content_filter%5B3%5D=1841596&content_filter%5B4%5D=1829196&content_filter%5B5%5D=1824731&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1841486&content_filter%5B1%5D=1841616&content_filter%5B2%5D=1841601&content_filter%5B3%5D=1841596&content_filter%5B4%5D=1829196&content_filter%5B5%5D=1824731&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1841486&content_filter%5B1%5D=1841616&content_filter%5B2%5D=1841601&content_filter%5B3%5D=1841596&content_filter%5B4%5D=1829196&content_filter%5B5%5D=1824731&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1841486&content_filter%5B1%5D=1841616&content_filter%5B2%5D=1841601&content_filter%5B3%5D=1841596&content_filter%5B4%5D=1829196&content_filter%5B5%5D=1824731&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1841486&content_filter%5B1%5D=1841616&content_filter%5B2%5D=1841601&content_filter%5B3%5D=1841596&content_filter%5B4%5D=1829196&content_filter%5B5%5D=1824731&&format=ris) ### 2024 Kazer S, Match CM, Langan E, Messou M-A, LaSalle T, O’Leary E, Marbourg J, Naughton K, Andrian U, Ordovas-Montanes J. [Primary nasal viral infection rewires the tissue-scale memory response](/publications/primary-nasal-viral-infection-rewires-tissue-scale-memory-response). Immunity. 2024 Aug 13;57(8):1955-1974.e8. 2024. doi:10.1101/2023.05.11.539887 Kazer S, Match CM, Langan E, Messou M-A, LaSalle T, O’Leary E, Marbourg J, Naughton K, Andrian U, Ordovas-Montanes J. [Primary nasal viral infection rewires the tissue-scale memory response](/publications/primary-nasal-viral-infection-rewires-tissue-scale-memory-response). Immunity. 2024 Aug 13;57(8):1955-1974.e8. 2024. doi:10.1101/2023.05.11.539887 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38964332/) - [ picture\_as\_pdfKazer et al Immunity pdf](/sites/g/files/omnuum3666/files/primary_nasal_influenza_infection_rewires_tissue-scale_memory_response_dynamics.pdf) The nasal mucosa is frequently the initial site of respiratory viral infection, replication, and transmission. Recent work has started to clarify the independent responses of epithelial, myeloid, and lymphoid cells to viral infection in the nasal mucosa... - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38964332/) - [ picture\_as\_pdfKazer et al Immunity pdf](/sites/g/files/omnuum3666/files/primary_nasal_influenza_infection_rewires_tissue-scale_memory_response_dynamics.pdf) Xia M, Stegmeyer R, Shirakura K, Butz S, Thiriot A, Andrian U, Vestweber D. [Conditions that promote transcellular neutrophil migration in vivo](/publications/conditions-promote-transcellular-neutrophil-migration-vivo). Sci Rep. 2024;14(1):14471. doi:10.1038/s41598-024-65173-3 Xia M, Stegmeyer R, Shirakura K, Butz S, Thiriot A, Andrian U, Vestweber D. [Conditions that promote transcellular neutrophil migration in vivo](/publications/conditions-promote-transcellular-neutrophil-migration-vivo). Sci Rep. 2024;14(1):14471. doi:10.1038/s41598-024-65173-3 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38914623/) - [ picture\_as\_pdfXia et al Sci Rep.pdf](/sites/g/files/omnuum3666/files/conditions_that_promote_transcellular_neutrophil_migration_in_vivo.pdf) Circulating leukocytes enter tissue either through endothelial junctions (paracellular) or via a pore through the body of endothelial cells (transcellular). We have previously shown that genetically replacing VE-cadherin with a VE-cadherin-α-catenin (VEC... - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38914623/) - [ picture\_as\_pdfXia et al Sci Rep.pdf](/sites/g/files/omnuum3666/files/conditions_that_promote_transcellular_neutrophil_migration_in_vivo.pdf) Wang T, Kaneko S, Kriukov E, Alvarez D, Lam E, Wang Y, La Manna S, Marasco D, Fernandez-Gonzalez A, Mitsialis A, et al. [SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages](/publications/socs3-regulates-pathological-retinal-angiogenesis-through-modulating-spp1). Mol Ther. 2024;32(5):1425–1444. doi:10.1016/j.ymthe.2024.03.025 Wang T, Kaneko S, Kriukov E, Alvarez D, Lam E, Wang Y, La Manna S, Marasco D, Fernandez-Gonzalez A, Mitsialis A, et al. [SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages](/publications/socs3-regulates-pathological-retinal-angiogenesis-through-modulating-spp1). Mol Ther. 2024;32(5):1425–1444. doi:10.1016/j.ymthe.2024.03.025 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38504518/) - [ picture\_as\_pdfWang et al Mol Ther.pdf](/sites/g/files/omnuum3666/files/socs3_regulates_pathological_retinal_angiogenesis_through_modulating_spp1_expression_in_microglia_and_macrophages.pdf) Pathological ocular angiogenesis has long been associated with myeloid cell activation. However, the precise cellular and molecular mechanisms governing the intricate crosstalk between the immune system and vascular changes during ocular... - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38504518/) - [ picture\_as\_pdfWang et al Mol Ther.pdf](/sites/g/files/omnuum3666/files/socs3_regulates_pathological_retinal_angiogenesis_through_modulating_spp1_expression_in_microglia_and_macrophages.pdf) Raslan A, Pham T, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor A, Caporarello N, et al. [Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis](/publications/lung-injury-induced-activated%C2%A0endothelial-cell-states-persist-aging). Nat Commun. 2024;15(1):5449. doi:10.1038/s41467-024-49545-x Raslan A, Pham T, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor A, Caporarello N, et al. [Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis](/publications/lung-injury-induced-activated%C2%A0endothelial-cell-states-persist-aging). Nat Commun. 2024;15(1):5449. doi:10.1038/s41467-024-49545-x - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38937456/) - [ picture\_as\_pdfRaslan et al Nat Commun.p...](/sites/g/files/omnuum3666/files/lung_injury-induced_activated_endothelial_cell_states_persist_in_aging-associated_progressive_fibrosis.pdf) Progressive lung fibrosis is associated with poorly understood aging-related endothelial cell dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed single cell RNA-sequencing of bleomycin-injured lungs from young and... - [ descriptionPublisher's Version](https://pubmed.ncbi.nlm.nih.gov/38937456/) - [ picture\_as\_pdfRaslan et al Nat Commun.p...](/sites/g/files/omnuum3666/files/lung_injury-induced_activated_endothelial_cell_states_persist_in_aging-associated_progressive_fibrosis.pdf) Hanč P, Andrian U. [No pain, no gain - how nociceptors orchestrate tissue repair](https://www.nature.com/articles/s41422-024-00979-4). Cell Research 2024 May 23. doi: 10.1038/s41422-024-00979-4. 2024. Hanč P, Andrian U. [No pain, no gain - how nociceptors orchestrate tissue repair](https://www.nature.com/articles/s41422-024-00979-4). Cell Research 2024 May 23. doi: 10.1038/s41422-024-00979-4. 2024. - add\_circle do\_not\_disturb\_on Abstract - [ picture\_as\_pdfHanc-Andrian Cell Researc...](/sites/g/files/omnuum3666/files/s41422-024-00979-4.pdf) **Pain-sensing peripheral neurons, nociceptors, exert control over many aspects of the immune response through various means, including the secretion of immunomodulatory molecules. Adding to the growing list of such interactions, a recent article by Lu et**... - [ picture\_as\_pdfHanc-Andrian Cell Researc...](/sites/g/files/omnuum3666/files/s41422-024-00979-4.pdf) Price S, Oakes RS, Gonzalez RJ, Edwards C, Brady A, DeMarco JK, Andrian U, al. [Microneedle array delivery of Yersinia pestis recapitulates bubonic plague](/publications/microneedle-array-delivery-yersinia-pestis-recapitulates-bubonic-plague). iScience. 2024. doi:10.1016/j.isci.2023.108600 Price S, Oakes RS, Gonzalez RJ, Edwards C, Brady A, DeMarco JK, Andrian U, al. [Microneedle array delivery of Yersinia pestis recapitulates bubonic plague](/publications/microneedle-array-delivery-yersinia-pestis-recapitulates-bubonic-plague). iScience. 2024. doi:10.1016/j.isci.2023.108600 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2589004223026779?via%3Dihub) Fleas transmit [*Yersinia pestis*](https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/yersinia-pestis) directly within the dermis of mammals to cause bubonic plague. Syringe-mediated inoculation is widely used to recapitulate bubonic plague and study *Y. pestis* pathogenesis. However, [intradermal](https://www.sciencedirect.com/topics/chemistry/intradermal) needle inoculation is tedious... - [ descriptionPublisher's Version](https://www.sciencedirect.com/science/article/pii/S2589004223026779?via%3Dihub) [ More arrow\_circle\_right ](/publications)