@article {1526301,
	title = {Cosmc controls B cell homing},
	journal = {Nature Communications},
	volume = {11},
	number = {3990},
	year = {2020},
	abstract = {The molecular mechanisms regulating lymphocyte homing into lymph nodes are only partly understood. Here, we report that B cell-specific deletion of the X-linked gene,\&nbsp;Cosmc, and the consequent decrease of protein O-glycosylation, induces developmental blocks of mouse B cells. After transfer into wild-type recipient,\&nbsp;Cosmc-null B cells fail to home to lymph nodes as well as non-lymphoid organs. Enzymatic desialylation of wild-type B cells blocks their migration into lymph nodes, indicating a requirement of sialylated O-glycans for proper trafficking. Mechanistically,\&nbsp;Cosmc-deficient B cells have normal rolling and firm arrest on high endothelium venules (HEV), thereby attributing their inefficient trafficking to alterations in the subsequent transendothelial migration step. Finally,\&nbsp;Cosmc-null B cells have defective chemokine signaling responses. Our results thus demonstrate that\&nbsp;Cosmc\&nbsp;and its effects on O-glycosylation are important for controlling B cell homing.},
	author = {Zeng, J and Eljalby, M and Aryal, R and Lehoux, S and Stavenhagen, K and Kudelka, M and Wang, Y. and Wang, J. and Ju, T and von Andrian, U. H. and Cummings, R}
}
