Sam worked with Alex Shalek at MIT during his PhD, learning to apply and integrate both experimental and computational single-cell genomics methods to study the longitudinal immune dynamics of acute HIV infection. Inspired data revealing of subsets of innate immune cells associating with antiviral control, Sam joined the labs of Dr. von Andrian and Dr. Ordovas-Montanes (Boston Children’s Hospital) to learn experimental immunology in more tenable models. Sam is working jointly to explore the role of trained immunity/inflammatory memory at mucosal tissues during viral infection.