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von Andrian Lab Videos

 

NOCICEPTIVE SENSORY NEURONS DRIVE INTERLEUKIN-23 MEDIATED PSORIASIFORM SKIN INFLAMMATION

For details on experimental methods & techniques see:

Riol-Blanco, L., Ordovas-Montanes, J., Perro, M., Naval, E., Thiriot, A., Alvarez, D., Paust, S., Wood, J.H., and von Andrian, U.H. Nociceptive sensory neurons drive interleukin-23 mediated psoriasiform skin inflammation. Nature, ePub 2014, April 23.[Full Text PDF] [Supplementary Material]

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ONTOGENETIC REGULATION OF LEUKOCYTE RECRUITMENT IN THE MOUSE YOLK SAC MICROVESSELS
For details on experimental methods & techniques see:

Sperandio, M, Quackenbush, E., Sushkova, N., Nussbaum, C., Schmidt, S., Prünster, M., Kurz, A., Margraf, A., Steppner, A., Schweiger, N., Boros, I., Krajewski, N., Genzel-Boroviczeny, O., Jeschke, U., Frommhold, D. and von Andrian, U.H. Ontogenetic regulation of leukocyte recruitment in the mouse yolk sac microvessels. Blood. 2013 May 23;121(21):e118-28. Epub 2013 Mar 22.[Full Text PDF][Supplementary Material]

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T CELL SENSING OF ANTIGEN DOSE GOVERNS INTERACTIVE BEHAVIOR WITH DENDRITIC CELLS AND SETS A THRESHOLD FOR T CELL ACTIVATION
For details on experimental methods & techniques see:

Henrickson, S.E., Mempel, T.R., Mazo, I.B., Liu, B., Flynn, M., Artomov, M., Junt, T., Wong, H.C., Chakraborty, A.K. and von Andrian, U.H. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nature Immunology, 9(3):282-291, 2008. [Full Text PDF][Supplementary Material]

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SUBCAPSULAR SINUS MACROPHGES IN LYMPH NODES CLEAR LYMPH-BORNE VIRUSES AND PRESENT THEM TO ANTIVIRAL B CELLS
For details on experimental methods & techniques see:

Junt, T., Moseman, E.A., Boes, M., Fink, K., Shayakhmetov, D.M., Mempel, T.R., Whelan, S.P. and von Andrian, U.H. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature, 2007 Oct 14; [Epub ahead of print] PMID: 17934446.[Full Text and Supplementary PDF]

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DYNAMIC VISUALIZATION OF THROMBOPOIESIS WITHIN BONE MARROW
For details on experimental methods & techniques see:

Junt, T., Schulze, H., Chen, Z., Massberg, S., Goerge, T., Krüger, A., Richardson, J., Graf, T., Italiano, J., Shivdasani, R. and von Andrian, U.H. Dynamic visualization of thrombopoiesis within bone marrow. Science, September; 317: 1767-1770, 2007. [Full Text PDF][Supplementary Material PDF]

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REGULATORY T CELLS REVERSIBLY SUPPRESS CYTOTOXIC T CELL FUNCTION INEPENDENT OF EFFECTOR DIFFERENTIATION
For details on experimental methods & techniques see:

Mempel, T.R., Pittet, M.J., Khazaie, K., Weninger, W., Weissleder, R. von Boehmer, H. and von Andrian, U.H., Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 25(1):129-141, 2006.[Full Text and Supplementary Materials PDF]

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BONE MARROW IS A MAJOR RESERVOIR AND SITE OF RECRUITMENT FOR CENTRAL MEMORY CD8+ T CELLS
For details on experimental methods & techniques see:

Mazo, I.B., Honczarenko, M., Leung, H., Cavanagh, L.L., Bonasio, R., Weninger, W., McEver, R., Koni, P.A., Silberstein, L.E. and von Andrian, U.H., Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity. 22:259-270, 2005. [Full Text PDF][Supplementary Material PDF]

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THE S1P-ANALOG FTY720 DIFFERENTIALLY MODULATES T CELL HOMING VIA HEV
For details on experimental methods & techniques see:

Halin, C., Scimone, M.L., Gauguet, J.-M., Mempel, T.R., Quackenbush, E.J., Proia, R., Mandala, S. and von Andrian, U.H. The S1P-analog FTY720 differentially modulates T cell homing via HEV: T cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer’s patches. Blood, 106(4): 1314-1322, 2005.

[Full Text PDF]

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INTRAVITAL MICROSCOPY - VISUALIZING IMMUNITY IN CONTEXT
For details on experimental methods & techniques see:

Sumen, C., Mempel, T.R., Mazo, I.B. and von Andrian, U.H. Intravital microscopy - visualizing immunity in context. Immunity 21(3): 315-329, 2004.
[Full Text PDF]

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T CELL PRIMING BY DENDRITIC CELLS IN LYMPH NODES

For details on experimental methods & techniques see:

Mempel, T.R., Henrickson, S.E. and von Andrian, U.H. T cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159, 2004. [Full Text PDF]

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HOMING AND CELLULAR TRAFFIC IN LYMPH NODES

For details on experimental methods & techniques see:

von Andrian, U.H. and Mempel, T. Homing and Cellular Traffic in Lymph Nodes. Nature Reviews Immunology 3: 867-878, 2003. [Full Text PDF]

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A NOVEL ENDOTHELIAL L-SELECTIN LIGAND ACTIVITY IN LYMPH NODE MEDULLA

For details on experimental methods & techniques see:

M'Rini, C., Cheng, G., Schweitzer, C., Cavanagh, L.L., Palframan, R.T., Mempel, T., Warnock, R.A., Lowe, J.B., Quackenbush, E.J., and von Andrian, U.H. A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha (1,3)-fucosyltransferase-IV. .J. Exp. Med. 198(9) : 1301-1312, 2003.[Full Text PDF]

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THE CC CHEMOKINE THYMUS-DERIVED CHEMOTACTIC AGENT 4 (TCA-4, SECONDARY TISSUE CHEMOKINE, 6CKINE, EXODUS-2) TRIGGERS LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 1-MEDIATED ARREST OF ROLLING T LYMPHOCYTES IN PERIPHERAL LYMPH NODE HIGH ENDOTHELIAL VENULES.

For details on experimental methods & techniques see:

Stein, J.V., Rot, A., Luo, Y., Narasimhaswamy, M., Nakano, H., Gunn, M.D., Matsuzawa, A., Quackenbush, E.J. Dorf, M.E., and von Andrian, U.H. The CC Chemokine Thymus-derived Chemotactic Agent 4 (TCA-4, Secondary Lymphoid Tissue Chemokine, 6Ckine, Exodus-2) Triggers Lymphocyte Function-associated Antigen 1-mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules. J. Exp. Med. 191: 61-75, 2000.[Full Text PDF]

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HEMATOPOIETIC PROGENITOR CELL ROLLING IN BONE MARROW MICROVESSELS

For details on experimental methods & techniques see:

Mazo, I.B., Guttierrez-Ramos, J.-C., Frenette, P., Wagner, D.D., Hynes, R.O., and von Andrian, U.H. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and Vascular Cell Adhesion Molecule 1. J. Exp. Med. 188: 465-474, 1998.[Full Text PDF]

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